National Institutes of Health (NIH)

Slots: One. Moreover, institutions with C06 awards funded under the Biomedical Research Facility Program (FOAs PAR-19-128, PAR-20-086, or PAR-21-139) are not eligible to apply to this FOA, provided the awards are active on the receipt date for this FOA (March 15, 2022). Thus, only one C06 Biomedical Research Facility active award per institution would be allowed at any given time.

Deadlines

Internal Deadline: Friday, January 21st, 2022, 5pm PT

LOI: February 15, 2022

External Deadline: March 15, 2022

Award Information

Award Type: Grant

Estimated Number of Awards: The number of awards is contingent upon NIH construction appropriation and the submission of a sufficient number of meritorious applications.

Anticipated Award Amount: The maximum award budget is $8,000,000. Applications with a budget less than $3,000,000 will not be considered. 

Who May Serve as PI: The PD/PI should hold appropriate stature within the institutional administration structure and be able to oversee various facets of the entire construction/modernization project. The PD/PI should also demonstrate his/her leadership skills to recruit and guide expert Key Personnel with complementary scientific and technical skills to successfully plan, design, and accomplish the construction project.

Link to Award: https://grants.nih.gov/grants/guide/pa-files/PAR-22-088.html

Process for Limited Submissions

PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://orif.usc.edu/oor-portal/.

Materials to submit include:

• (1) Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt). Page limit includes references and illustrations. Pages that exceed the 1-page limit will be excluded from review.
• (2) CV – (5 pages maximum)

Note: The portal requires information about the PIs and Co-PIs in addition to department and contact information, including the 10-digit USC ID#, Gender, and Ethnicity. Please have this material prepared before beginning this application.

Purpose

This Funding Opportunity Announcement (FOA) invites qualified institutions of higher education and research organizations to seek funding to modernize and improve existing shared-use research facilities (e.g., core laboratory space or animal facilities), or to construct new biomedical research space and furnish it with necessary casework or other fixed equipment (subject to requirements described below under Funding Restrictions). The objective of this FOA is to support the development of modern facilities that will enable and enhance the conduct of cutting-edge biomedical research. Any facility supported by this FOA must serve a broad research community, locally at the applicant institution or regionally.

NIH recognizes that modern physical infrastructure is necessary for the conduct of cutting-edge research. As science progresses and new technologies become available, dedicated space is required to house specialized equipment and to carry out novel experimental protocols. Projects will vary and depend on the present institutional infrastructure and long-term institutional strategic plans. Focusing on the advancement of science through the modernization of physical space will be a common and integral feature of all proposed projects. When completed, construction/modernization projects will have a significant institution-wide impact, bringing the research capacities and capabilities to a new level. An institution may request funds to modernize a core facility to create an environment required for research-driven specialized technological services. Likewise, funds may be requested to consolidate space for an institution-wide core which would provide streamlined workflows for contemporary multi-disciplinary investigations. Modernizing laboratory space used on a shared basis to meet the growing needs consistent with an institutional strategic vision for biomedical research is another example of a suitable request. A successful construction/modernization project will serve research teams and a broad range of research efforts. Laboratory space dedicated to an individual PI and their immediate laboratory is not supported under this FOA.

Various factors are typically considered when developing or modernizing research infrastructure. For applications submitted to this FOA, defined research needs will drive the requests for modern engineering solutions. As science progresses and new technologies become available, required dedicated space must comply with relevant technical specifications to provide a well-controlled environment, to enable novel experimental approaches, and to house specialized equipment. It is encouraged that these new spaces adhere to the highest possible standards of green design engineering and operations.

Modern physical infrastructure requires the implementation of advanced engineering designs. Some protocols may only be conducted in designated clean rooms, such as barrier facilities for pathogen-free research or space for synthesis of compounds meeting standards for human subject experiments. Certain equipment requires specially shielded rooms or rigorous control of environmental variables such as temperature or humidity. The shared space also needs to be adequately maintained to serve its desired function over the years. The formal structure of an institutional core typically offers effective oversight to ensure that the required engineering standards of a space it occupies are met and maintained over time. Also, such centralized facilities are organized to provide rigorous scientific support for the conduct of research.

Visit our Institutionally Limited Submission webpage for more updates and other announcements.

Slots: 1

Deadlines

Internal Deadline: Friday, March 4, 2022, 5pm PT

LOI: 30 days prior to the application due date.

External Deadline: June 3, 2022     

Award Information

Award Type: Cooperative Agreement

Estimated Number of Awards: 4-5

Anticipated Award Amount: $7.674 million

Who May Serve as PI:  Note that the multiple PD(s)/PI(s) option may be used only for the Overall Program. Projects are limited to a single project lead per project and a single core lead per core within the multi-component application.

An investigator can serve as a PD/PI on only one AADCRC award or application. This includes all PD(s)/PI(s) of a multiple-PD/PI application.

Note that the current FOA will not allow foreign clinical trial sites. However, foreign components that will be allowed include mechanistic projects, observational studies, specialized assay, etc.

Link to Award: https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-21-079.html

Process for Limited Submissions

PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://orif.usc.edu/oor-portal/.

Materials to submit include:

• (1) Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt). Page limit includes references and illustrations. Pages that exceed the 1-page limit will be excluded from review.
• (2) CV – (5 pages maximum)

Note: The portal requires information about the PIs and Co-PIs in addition to department and contact information, including the 10-digit USC ID#, Gender, and Ethnicity. Please have this material prepared before beginning this application.

Purpose

This Funding Opportunity Announcement (FOA) invites applications from single institutions or consortia of institutions to participate in the Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program. The program will support centers that integrate clinical and translational research to conduct studies on the mechanisms underlying the onset and progression of diseases of interest including asthma, rhinitis (allergic and non-allergic), chronic rhinosinusitis, atopic dermatitis, food allergy, and drug allergy. The overarching goal of the program is to improve the understanding of the pathogenesis of these conditions and to provide a rational foundation for new, effective treatments and prevention strategies.

                                                                The objective of this FOA is to support multidisciplinary research on the following conditions of interest: immunopathophysiology of asthma, rhinitis (allergic and non-allergic), chronic rhinosinusitis, atopic dermatitis, food allergy, and drug allergy. The overall goal of the AADCRC program is to improve the understanding of the pathogenesis of these conditions and to provide a rational foundation for new, effective treatments and prevention strategies.

NIAID programmatic priorities for this FOA are:

1. The role of innate and adaptive immune functions in the development and pathogenesis of asthma and allergic diseases with a focus on severe asthma, chronic rhinosinusitis, atopic dermatitis, and drug allergy;
2. The impact of the microbiome and of pollution on immune responses as they pertain to the development, prevention and management of asthma, allergic rhinitis, food allergy and atopic dermatitis;
3. The interaction between infections and atopy and the role of immune responses to infections in the development and exacerbations of asthma, allergic rhinitis, chronic rhinosinusitis, and atopic dermatitis;
4. Understanding the mechanisms of allergen immunotherapy-induced clinical desensitization and tolerance for the treatment and prevention of asthma, allergic rhinitis and food allergy and improving the efficacy, safety and ease of use of this therapeutic modality;
5. Identifying genetic variations and epigenetic alterations affecting host immune responses to aeroallergens, food allergens and drug allergens and patient responses to therapeutic interventions in asthma, allergic rhinitis, chronic rhinosinusitis, atopic dermatitis and drug allergy;
6. Clinical, immunologic and physiologic phenotyping and endotyping of drug allergy, chronic rhinosinusitis and non-allergic rhinitis syndromes that provide mechanistic insights for disease etiology or management.

Visit our Institutionally Limited Submission webpage for more updates and other announcements.

Slots: 1

Deadlines

Internal Deadline: Monday, December 13^th, 5pm PT

External Deadline: January 27, 2022

Award Information

Award Type: Grant

Estimated Number of Awards: Up to 14

Anticipated Number of Awards: The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Anticipated Award Amount: The total direct costs for each award are limited to $400,000 annually. 

Who May Serve as PI:

As described in the instructions for the Program Director(s)/Principal

Investigator(s) (PD(s)/PI(s)) in Section IV.2 below, NIGMS encourages multiple PD(s)/PI(s), particularly when each brings a unique perspective and skill set that will enhance the research education program. The PD(s)/PI(s) must be able to provide both administrative and scientific leadership to the development and implementation of the proposed program. At least one of the PD(s)/PI(s) should be an established investigator in the biomedical sciences. Additional PD(s)/PI(s), including individuals with experience in the science of education, relevant social science disciplines, program evaluation, mentoring, and university administration may be included to achieve the program goals. Any of the PD(s)/PI(s) may serve as the contact PD/PI. The contact PD/PI is expected to have a full-time appointment at the applicant institution unless extremely well-justified. If the full-time status of the contact PD/PI changes after the award, the institution must obtain prior program approval to appoint a new PD/PI or request a deviation from the full-time rule. The PD(s)/PI(s) will be responsible for the selection and appointment of participants to the approved research education program, and for the overall direction, management, administration, and evaluation of the program. The PD(s)/PI(s) will be expected to monitor and assess the program and submit all documents and reports as required. The PD(s)/PI(s) have responsibility for the day-to-day administration of the program and are responsible for appointing members of the Advisory Committee (when applicable) and using their recommendations to determine the appropriate allotment of funds.

Link to Award: https://grants.nih.gov/grants/guide/pa-files/par-20-066.html

Process for Limited Submissions

PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://orif.usc.edu/oor-portal/.

Materials to submit include:

• (1) Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt). Page limit includes references and illustrations. Pages that exceed the 1-page limit will be excluded from review.
• (2) CV – (5 pages maximum)

Note: The portal requires information about the PIs and Co-PIs in addition to department and contact information, including the 10-digit USC ID#, Gender, and Ethnicity. Please have this material prepared before beginning this application.

Purpose

The over-arching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research.

To accomplish the stated overarching goal, this FOA will support creative educational activities with a primary focus on:

1. Research Experiences: For example, to provide hands-on exposure to research, to prepare participants for graduate school admissions, successful completion of a research-focused doctoral degree, and careers in the biomedical research workforce.
2. Courses for Skills Development: For example, to provide advanced courses in a specific discipline, research technique or research area, and/or courses or workshops to develop scholarly potential to prepare participants for graduate school admissions, successful completion of a research-focused doctoral degree, and careers in the biomedical research workforce.

The Overarching Objective of PREP is to develop a diverse pool of well-trained postbaccalaureate participants who will transition into and complete rigorous biomedical, research-focused doctoral degree programs (e.g., Ph.D. or M.D./Ph.D.) in biomedical fields relevant to the NIGMS mission. The long-term goal is to develop a diverse pool of well-trained biomedical scientists, who have the following technical, operational, and professional skills:

A broad understanding across biomedical disciplines and the skills to independently acquire the knowledge needed to advance their chosen fields;

The ability to think critically and independently, and to identify important biomedical research questions and approaches that push forward the boundaries of their areas of study;

A strong foundation in scientific reasoning, rigorous research design, experimental methods, quantitative and computational approaches, and data analysis and interpretation;

A commitment to approaching and conducting biomedical research responsibly, ethically, and with integrity;

Experience initiating, conducting, interpreting, and presenting rigorous and reproducible biomedical research with increasing self-direction;

The ability to work effectively in teams with colleagues from a variety of cultural and scientific backgrounds, and to promote inclusive and supportive scientific research environments;

The skills to teach and communicate scientific research methodologies and findings to a wide variety of audiences (e.g., discipline-specific, across disciplines, and the public); and

The knowledge, professional skills and experiences required to identify and transition into careers in the biomedical research workforce (i.e., the breadth of careers that sustain biomedical research in areas that are relevant to the NIH mission).

Diversity at all levels contributes to excellence in research environments and strengthens the research enterprise. This FOA is intended to support outstanding research education programs that will enhance diversity at all levels.

Visit our Institutionally Limited Submission webpage for more updates and other announcements.