Internal Deadline: Friday, November 12, 2021, 5pm PT
LOI: January 15, 2022
External Deadline: February 15, 2022
Award Type: Cooperative Agreement
Estimated Number of Awards: 1
Anticipated Award Amount: Estimated total of $3 million
Who May Serve as PI: Standard NIH requirements.
Process for Limited Submissions
PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://orif.usc.edu/oor-portal/.
Materials to submit include:
- (1) Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt). Page limit includes references and illustrations. Pages that exceed the 1-page limit will be excluded from review.
- (2) CV – (5 pages maximum)
Note: The portal requires information about the PIs and Co-PIs in addition to department and contact information, including the 10-digit USC ID#, Gender, and Ethnicity. Please have this material prepared before beginning this application.
The purpose of this Funding Opportunity Announcement (FOA) is to establish a mechanistic omics center (SUNBEAM-ABC) to support the birth cohort study Systems Biology of Early Atopy (SUNBEAM). The center will assay biologic samples collected in SUNBEAM using omics and systems biology approaches to identify determinants of atopic disease, focusing on food allergy and atopic dermatitis (AD) in newborns, infants, and very young children. SUNBEAM-ABC will support the SUNBEAM birth cohort study by providing analytic infrastructure to comprehensively understand molecular and cellular pathways that contribute to atopic disease development and to identify early predictive biomarkers.
SUNBEAM-ABC will create a discovery infrastructure that will explore SUNBEAM biologic samples and conduct systems level analyses in order to contribute to the goals of the SUNBEAM cohort. In pursuing its objectives, the SUNBEAM-ABC will work collaboratively with the SUNBEAM Steering Group and with the NIAID Statistical and Clinical Coordinating Center. The SUNBEAM-ABC PD/PI(s) will become members of the SUNBEAM Steering Group.
SUNBEAM-ABC will have the option of generating its own database(s) for the storage of laboratory data generated from the SUNBEAM sample assays or, in close collaboration with the NIAID Statistical and Clinical Coordinating Center, utilize the SUNBEAM database for this purpose. Any database(s) utilized for laboratory data storage must be selected and configured to provide smooth and easy functions for combining the SUNBEAM clinical and other laboratory data with the data generated by the SUNBEAM-ABC activities.
Applications in response to this FOA are required to include whole blood transcriptomics and high parameter cytometry analysis of fixed blood cells at a minimum. Other potential analyses of interest include, but are not limited to, serum/plasma proteomics, plasma metabolomics, and cellular studies using frozen viable peripheral blood mononuclear cells. Proposed analyses need to use established and validated laboratory assay methods and procedures.
Visit our Institutionally Limited Submission webpage for more updates and other announcements.